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DOE复合合意性是指在实验设计中，各处理组间的差异是否具备统计学上的显著性。这可以通过方差分析等方法来检验。判断DOE复合合意性的依据是处理组间的变异性与随机误差相比较，若差异显著，说明DOE复合合意，实验结果可信。